产品详情
产品名称TERT (phospho-Ser227) Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用IF/ICC,ELISA
种属反应性Human
特异性Phospho-TERT (S227) Polyclonal Antibody detects endogenous levels of TERT protein only when phosphorylated at S227.
免疫原描述The antiserum was produced against synthesized peptide derived from human Telomerase around the phosphorylation site of Ser227. AA range:196-245
标记Unconjugated
别名TERT; EST2; TCS1; TRT; Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
数据库入口号Swiss Prot:O14746
GeneID:7015
Uniprot
O14746
计算分子量126kd
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
Immunofluorescence: 1/200 - 1/1000.
ELISA: 1/10000. Not yet tested in other applications.
telomerase reverse transcriptase(TERT) Homo sapiens Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative sp
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et al,Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. In Nat Chem Biol on 2024 Nov
by Min Li, Zheng Wang,et al..PMID:38538923
, (2024),
PMID:
38538923
Yes
