产品详情
产品名称Stat3 (phospho-Ser754) rabbit pAb
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
应用WB
种属反应性Human;Mouse
特异性This antibody detects endogenous levels of Human Mouse Stat3 (phospho-Ser754)
免疫原描述Synthesized phosho peptide around human Stat3 (Ser754)
标记Unconjugated
别名Signal transducer and activator of transcription 3 (Acute-phase response factor)
数据库入口号Swiss Prot:P40763
GeneID:6774
Uniprot
P40763
实际分子量88
浓度1 mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存-20˚C/1
应用详情
WB 1:1000-2000
signal transducer and activator of transcription 3(STAT3) Homo sapiens The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
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et al,AHR Agonist ITE Boosted PD1 Antibody’s Effects by Inhibiting Myeloid-Derived Cells Suppressive Cells in an Orthotopic Mouse Glioma Model
, (2025),
PMID:
Yes
