产品详情
产品名称Tau Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB;IHC;IF;ELISA
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total Tau protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 394~398 (Y-K-S-P-V) derived from Human Tau.
基因/蛋白名称Tau
标记Unconjugated
别名Neurofibrillary tangle protein; Paired helical filament-tau;
数据库入口号Swiss-Prot: P10636
NCBI Protein: NP _001116538.1
Uniprot
P10636
计算分子量48 62 78 kDa
实际分子量50-80kDa
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:500; ELISA 1:20000;
Western blot analysis of extracts from Mouse brain using Tau Antibody.
Western blot analysis of extracts from A172, hela cells using Tau Antibody.
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer using Tau Antibody.
Immunofluorescence staining of methanol-fixed Hela cells using Tau Antibody.
Immunofluorescence analysis of U-251 MG cells using Tau Rabbit pAb at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunofluorescence analysis of rat brain using Tau Rabbit pAb at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunofluorescence analysis of mouse brain using Tau Rabbit pAb at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.
DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.
Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.
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