产品详情
产品名称JAK1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total JAK1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 1020~1024 (K-E-Y-Y-T) derived from Human JAK1.
基因/蛋白名称JAK1
标记Unconjugated
别名 Janus kinase 1
数据库入口号Swiss-Prot: P23458
NCBI Protein: NP_002218.2
Uniprot
P23458
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 130kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from 3T3, HepG2, HT29 and MDA cells using JAK1(Ab-1022) Antibody #21119.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1(Ab-1022) Antibody #21119(left) or the same antibody preincubated with blocking peptide(right).
Tyrosine kinase of the non-receptor type, involved in the IFN-a/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Wang R, et al. (2003) Arch Biochem Biophys. 410(1): 7-15.
如果您使用该产品21119发表了文章，请通知我们，让我们可以引用您的文献。
et al,A thiazole-derived oridonIn analogue exhibits antitumor activity by directly and allosterically InhibitIng STAT3. In J Biol Chem on 2019 Nov 15;by Shen X, Zhao L,et al..PMID:31594861
, (2019),
PMID:
31594861
et al,Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. In J Cancer Res Clin Oncol
on 2011 Nov by Dan Liu, Yi Huang, et al..PMID:21861134
, (2011),
PMID:
21861134
有货
