产品详情
产品名称HDAC4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB;IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total HDAC4 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 630~634 (A-Q-S-S-P) derived from Human HDAC4.
基因/蛋白名称HDAC4
标记Unconjugated
别名HD4; Histone deacetylase 4;
数据库入口号Swiss-Prot: P56524
NCBI Protein: NP_006028.2
Uniprot
P56524
计算分子量119kDa
实际分子量140kDa
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 140kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from HepG2 cells using HDAC4 antibody.
Western blot analysis of extracts from Rat womb, 293 and Hela cells using HDAC4 antibody.
Immunofluorescence staining of methanol-fixed Hela cells using HDAC4 Antibody.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.
Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.
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