产品详情
产品名称GAP43 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total GAP43 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.38~43 (Q-A-S-F-R) derived from Human GAP43.
基因/蛋白名称GAP43
标记Unconjugated
别名B-50; BASP2; NEUM; PP46; axonal membrane protein GAP-43
数据库入口号Swiss-Prot: P17677
NCBI Protein: NP_001123536.1
Uniprot
P17677
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 43kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from mouse brain tissue using GAP43(Ab-41) Antibody #21273 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GAP43(Ab-41) Antibody #21273(left) or the same antibody preincubated with blocking peptide(right).
Immunofluorescence staining of methanol-fixed Hela cells using GAP43(Ab-41) Antibody #21273.
GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Rachael L. Neve, et,al. (1998) J. Neurosci; 18: 7757.
Yiping Shen, et,al. (2002) J. Neurosci; 22: 239.
Chantal Gamby, et,al. (1996) J. Biol. Chem; 271: 26698.
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et al,Responses of PKCε to cardiac overloads on myocardial sympathetic innervation and NET expression.In Auton Neurosci. On 2018 Mar by Hu B, Zhang J et al..PMID:29195789
, (2018),
PMID:
29195789
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