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a-Synuclein Antibody#21278

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产品详情 图片 产品描述 发表文献(5) 其它
产品详情

产品名称a-Synuclein Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB;IF

种属反应性Human;Mouse;Rat

特异性The antibody detects endogenous level of total a-Synuclein protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Human α-Synuclein.

基因/蛋白名称a-Synuclein

标记Unconjugated

别名NACP; SYN; SYUA; alpha-synuclein;

数据库入口号Swiss-Prot: P37840
NCBI Protein: NP_000336.1

Uniprot P37840

计算分子量14kDa

实际分子量18kDa

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
WB 1:1000-1:2000; IF 1:50-1:200;
Western blot analysis of extracts from Hela and 3T3 cells using a-Synuclein Antibody.
Immunofluorescence staining of methanol-fixed Hela cells using a-Synuclein Antibody.
Immunofluorescence staining of methanol-fixed mouse brain tissue using a-Synuclein Antibody.
Immunofluorescence staining of methanol-fixedf Mouse brain tissue using a-Synuclein Antibody（red）.Blue:DAPI for nuclear staining.

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

Takahashi T, et al. J Biol Chem 2003 Oct 24; 278(43): 42225-33
Ahn BH, et al. J Biol Chem 2002 Apr 05; 277(14): 12334-42
Negro A, et al. FASEB J 2002 Feb; 16(2): 210-2
Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119. 

如果您使用该产品21278发表了文章，请通知我们，让我们可以引用您的文献。

et al,Expression and Subcellular Location of Alpha-Synuclein During Mouse-Embryonic Development , (2010),
PMID: 19885730
et al,Expression and Subcellular Location of Alpha-Synuclein During Mouse-Embryonic Development. In Cell Mol Neurobiol on 2010 Apr by Shan-chuan Zhong, Xue Luo, et al..PMID: 19885730 , (2010),
PMID: 19885730
et al,Alpha-synuclein loss in spinal muscular atrophy. In J Mol Neurosci on 2011 Mar by Gyula Acsadi, Xingli Li, et al..PMID: 20640532 , (2011),
PMID: 20640532
et al,Distribution of the Alpha-Synuclein in the Brain and the Primary Organs of the Rhesus Monkey. In Appl Biochem Biotechnol on 2021 Oct by Jin-Ling Yang, Jia-Hong Gao, et al..PMID:34097253 , (2021),
PMID: 34097253
et al,G protein subunit 伪 q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.In Oncol Rep on 2017 Apr by Yizhuo Wang , Huijie Xiao,et al..PMID: 28350126 , (2017),
PMID: 28350126

操作手册

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡
;

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