产品详情
产品名称Smad2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total Smad2 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 463~467 (C-S-S-M-S) derived from Human Smad2.
基因/蛋白名称Smad2
标记Unconjugated
别名Mad-related protein 2
数据库入口号Swiss-Prot: Q15796
NCBI Protein: NP_001003652.1
Uniprot
Q15796
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 60kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from Hela cells using Smad2(Ab-467) Antibody #21322.
Immunofluorescence staining of methanol-fixed Hela cells using Smad2(Ab-467) Antibody #21322.
Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.
Sang Gyun Kim et al. (2004) Mol Biol Cell. February; 15(2): 420
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et al,High glucose increases Cdk5 activity in podocytes via transforming growth factor-尾1 signaling pathway.In Exp Cell Res on 2014 Aug 15 by Yue Zhang, Hongbo Li et al..PMID: 24768698
, (2014),
PMID:
24768698
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