产品详情
产品名称Fas Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total Fas protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.323~327 (E-N-S-N-F) derived from human Fas .
基因/蛋白名称Fas
标记Unconjugated
别名FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen
数据库入口号Swiss-Prot:
P25445
NCBI Protein: NP_000034.1
Uniprot
P25445
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 40-50kd
Western blotting: 1:1000
Western blot analysis of extracts from HepG2, Hela and 293 cells using Fas Antibody #21419.
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Hahne, M. et al. (1995) Int Immunol 7, 1381-6.
Nagata, S. (1997) Cell 88, 355-65.
Green, D.R. and Ferguson, T.A. (2001) Nat Rev Mol Cell Biol 2, 917-24.
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et al,Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity.In Environ Toxicol Pharmacol on 2016 Jan by Feng Zhang , Li Chen et al..PMID:26645133
, (2016),
PMID:
26645133
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