产品详情
产品名称Caspase-9 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total Caspase 9 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
基因/蛋白名称Caspase 9
标记Unconjugated
别名ICE-like apoptotic protease 6
数据库入口号Swiss-Prot: P55211
NCBI Protein: NP_001220.2
Uniprot
P55211
计算分子量17kDa/30kDa/36kDa/46kDa
实际分子量46kDa
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 47 37 35kd
Western blotting: 1:1000
Western blot analysis of extracts from 293 and Hela cells using Caspase-9 Antibody.
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.
Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.
Li, P. et al. (1997) Cell 91, 479-489.
如果您使用该产品21422发表了文章，请通知我们，让我们可以引用您的文献。
et al,Anticancer effects of sodium butyrate on hepatocellular carcinoma cells in vitro. In Int J Mol Med on 2013 Apr by Hong-Gang Wang, Xiao-Dan Huang, et al..PMID:
23440283
, (2013),
PMID:
23440283
有货
