产品详情
产品名称ASPSCR1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total ASPSCR1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.
基因/蛋白名称ASPSCR1
标记Unconjugated
别名ASPL; RCC17; TUG; UBXD9; UBXN9
数据库入口号Swiss-Prot: Q9BZE9
NCBI Protein: NP_076988.1
Uniprot
Q9BZE9
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 70-75kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from HL60 cells using ASPSCR1 Antibody #21430.
Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.
Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
Bogan, J.S. et al. (2003) Nature 425, 727-33.
Yu, C. et al. (2007) J Biol Chem 282, 7710-22.
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