产品详情
产品名称FBXL3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Mouse
特异性The antibody detects endogenous levels of total FBXL3 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.1~5 (M-K-R-G-G) derived from mouse FBXL3
基因/蛋白名称FBXL3
标记Unconjugated
别名FBK; Ovtm; FBXL3; Fbl3a; AU041772
数据库入口号Swiss-Prot: Q8C4V4
NCBI Protein: NP_056637.1
Uniprot
Q8C4V4
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 49kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from NIH/3T3 cells using FBXL3 Antibody #21459.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.
"Winston J.T.,et al.(1999) Curr. Biol. 9:1180-1182.
Carninci P. et al. (2005)Science 309:1559-1563.
The MGC Project Team, (2004)Genome Res. 14:2121-2127.
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et al,Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly DefInes an Evolutionary Conserved SignalIng Mechanism. In Curr Biol on 2019 Jun 17 by RizzIni L, LevIne DC, et al..PMID:31155351
, (2019),
PMID:
31155351
et al,Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. In Proc Natl Acad Sci U S A on 2013 Mar 19 by Guangsen Shi, Lijuan Xing, et al..PMID: 23471982
, (2013),
PMID:
23471982
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