产品详情
产品名称E-Cadherin(CD324) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total E-Cadherin protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.
基因/蛋白名称E-Cadherin(CD324)
标记Unconjugated
别名CDH1; CDHE; UVO
数据库入口号Swiss-Prot: P12830
NCBI Protein: NP_004351.1
Uniprot
P12830
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 135kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from MCF-7 and HT29 cells using E-Cadherin(CD324) Antibody #21473
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010
Agiostratidou G. (2006)J. Neurochem. 96:1182-1188
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et al,N鈥憁ethyl鈥慛鈥憂itro鈥慛'鈥憂itrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2鈥憁ediated migration.In Mol Med Rep On 2016 Feb by Jie Cai , Mei Wang et al..PMID:26648448
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et al, Octamer-binding protein 4 affects the cell biology and phenotypic transition of lung cancer cells involving 尾-catenin/E-cadherin complex degradation.In Mol Med Rep
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