产品详情
产品名称CD22 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total CD22 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22.
基因/蛋白名称CD22
标记Unconjugated
别名SIGLEC2; FLJ22814; SIGLEC-2; MGC130020;
数据库入口号Swiss-Prot: P20273
NCBI Protein: NP_001762.2
Uniprot
P20273
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 140kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from Raji cells using CD22 Antibody #21492
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Doody G.M., Justement L.B., Delibrias C.C., Matthews R.J., Lin J., Thomas M.L., Fearon D.T. Science 269:242-244(1995)
Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.Eur. J. Immunol. 26:1246-1252(1996)
Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A.J. Exp. Med. 183:547-560(1996)
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