产品详情
产品名称VEGFR2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total VEGFR2 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 1057~1061 (P-D-Y-V-R) derived from Human VEGFR2.
基因/蛋白名称VEGFR2
标记Unconjugated
别名FLK1; KDR; VGFR2; VGR2; kinase insert domain receptor
数据库入口号Swiss-Prot: P35968
NCBI Protein: NP_002244.1
Uniprot
P35968
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 210 230kd
Western blotting: 1:1000
Western blot analysis of cell lysates using VEGFR2(Ab-1059) antibody(#21531) Lane 1 and 2: Huvec cell; Lane 3 HT29 cell)
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Zeng H, et al. (2001) J Biol Chem. 276(35): 32714-32719.
Dougher M, et al. (1999) Oncogene. 18(8): 1619-1627.
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et al,Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.In Nat Commun.On 2018 Dec 21 by Liu S, Zhang G et al..PMID: 30575721
, (2018),
PMID:
30575721
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