产品详情
产品名称STAT2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IHC
种属反应性Human
特异性The antibody detects endogenous level of total STAT2 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
基因/蛋白名称STAT2
标记Unconjugated
别名P113; ISGF-3; STAT113
数据库入口号Swiss-Prot: P52630
NCBI Protein: NP_005410.1
Uniprot
P52630
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 113kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from Hela cells using STAT2(Ab-690) Antibody #21536 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2(Ab-690) Antibody #21536(left) or the same antibody preincubated with blocking peptide(right).
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.
Fu, X. et al. (1992) Biochemistry 89, 7840-7843.
Park, C. et al. (2000) Immunity 13, 795-804.
Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.
Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
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et al,Expression of interferon effector gene SART1 correlates with interferon treatment response against hepatitis B infection. In Mediators Inflamm on 2016 by Yong Li, Chuanlong Zhu et al..PMID: 28077916
, (2016),
PMID:
28077916
et al,CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis.
, (2025),
PMID:
40122504
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