产品详情
产品名称NMDANR2B Subunit Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NMDANR2B Subunit protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.1250-1254(N-L-Y-D-I) derived from Human NMDANR2B Subunit.
基因/蛋白名称NMDANR2B Subunit
标记Unconjugated
别名NMDAR2B; NR2B;
数据库入口号Swiss-Prot: Q00960
NCBI Protein: NP_036706.1
Uniprot
Q00960
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 180kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from T98G cells using NMDANR2B Subunit Antibody #21560
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death
Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.Science 269:1737-1740(1995)
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.Mol. Cell. Neurosci. 11:161-172(1998)
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et al,Bisphenol-A Induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons Chemosphere. In Chemosphere on 2019 Aug by Wang H, Zhao P, et al..PMID: 31102917
, (2019),
PMID:
31102917
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