产品详情
产品名称GluR1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total GluR1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa. 831~835 (K-S-R-S-E) derived from Human GluR1
基因/蛋白名称GluR1
标记Unconjugated
别名GLR1; GLUH1; GRIA1; GluR-1; GluR-A
数据库入口号Swiss-Prot: P42261
NCBI Protein: NP_000818.2
Uniprot
P42261
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 110kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from mouse brain and using GluR1 Antibody #21575.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Emamian ES, et al. (2004) J Neurosci. 24(7): 1561-4
Palmer, C.L. et al. (2005) Pharmacol. Rev. 57, 253-277.
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et al,Acid-sensing Ion Channel 1a Is Required for mGlu Receptor Dependent Long-Term Depression in the Hippocampus.In Pharmacol Res on 2017 May by D Mango, E Braksator,et al..PMID: 28137639
, (2017),
PMID:
28137639
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