产品详情
产品名称ERAB Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total ERAB protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
基因/蛋白名称ERAB
标记Unconjugated
别名ABAD; CAMR; HCD2; MHBD; HADH2
数据库入口号Swiss-Prot: Q99714
NCBI Protein: NP_004484.1
Uniprot
Q99714
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 27kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Antibody #21602
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008)
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