产品详情
产品名称FoxA2(HNF3b) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total FoxA2(HNF3b) protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.435~439( A-S-P-L-A) derived from Human FoxA2(HNF3b).
基因/蛋白名称FoxA2(HNF3b)
标记Unconjugated
别名HNF3B; TCF3B;
数据库入口号Swiss-Prot: Q9Y261
NCBI Protein: NP_068556.2
Uniprot
Q9Y261
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 50kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from 293, HT29, HepG2 cells using FoxA2(HNF3b) Antibody #21607.
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Wolfrum C., Besser D., Luca E., Stoffel M. Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003)
Motallebipour M., Ameur A., Reddy Bysani M.S. Genome Biol. 10:R129.0-R129.0(2009)
Nock A., Ascano J.M., Jones T., Barrero M.J. J. Biol. Chem. 284:19915-19926(2009)
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