产品详情
产品名称LPAM-1(Integrin a4, CD49d) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total LPAM-1(Integrin a4, CD49d) protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.1024~1028(Y-I-N-S-K) derived from Human LPAM-1(Integrin a4, CD49d).
基因/蛋白名称LPAM-1(Integrin a4,CD49d)
标记Unconjugated
别名IA4; MGC90518; ITGA4
数据库入口号Swiss-Prot: P13612
NCBI Protein: NP_000876.3
Uniprot
P13612
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 70 140 180kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from JK and Raji cells using LPAM-1(Integrin a4, CD49d) Antibody #21616
Integrins a-4/beta-1 (VLA-4) and a-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin a-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin a-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Iida J., Meijne A.M.L., Oegema T.R. Jr. J. Biol. Chem. 273:5955-5962(1998)
Liu S., Thomas S.M., Woodside D.G., Rose D.M. Nature 402:676-681(1999)
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