产品详情
产品名称C-Fos Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total C-Fos protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.28~32( S-Y-Y-H-S) derived from Human C-Fos.
基因/蛋白名称C-Fos
标记Unconjugated
别名p55; AP-1;
数据库入口号Swiss-Prot: P01100
NCBI Protein: NP_005243.1
Uniprot
P01100
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 62kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from A549, Hela and 3T3 cells using C-Fos Antibody #21667.
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Okazaki K., Sagata N.EMBO J. 14:5048-5059(1995)
Zhang Y., Feng X.H., Derynck R.Nature 394:909-913(1998)
Bossis G., Malnou C.E., Farras R. Mol. Cell. Biol. 25:6964-6979(2005)
如果您使用该产品21667发表了文章，请通知我们，让我们可以引用您的文献。
et al,Piperine alleviates osteoclast formation through the p38/c鈥怓os/NFATc1 signaling axis.In Biofactors on Nov-Dec 2015 by Vishwa Deepak , Marlena C Kruger et al..PMID: 26627060
, (2015),
PMID:
26627060
有货
