产品详情
产品名称Cytochrome C Antibody
来源种属Rabbit
克隆性Polyclonal
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total Cytochrome C protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.71-75(N-P-K-K-Y) derived from Human Cytochrome C.
基因/蛋白名称Cytochrome C
标记Unconjugated
别名CYC, HCS, THC4,
Uniprot
P99999
浓度1.0mg/ml
应用详情
Predicted MW: 14kd
Western blotting: 1: 500~1: 1000
Western blot analysis of extracts from 3T3, C6 and A549 cells using Cytochrome C Antibody #21680.
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
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et al,The role of InsulIn-like growth factor 1 In ALS cell and mouse models: A mitochondrial protector. In BraIn Res Bull on 2019 Jan by Wen D, Cui C et al..PMID:30414993
, (2019),
PMID:
30414993
et al,PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.In Sci Rep on 2020 Jan 24; by Honda T, Inui M. et al..PMID:31980707
, (2020),
PMID:
31980707
et al,PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.In Sci Rep on 2020 Jan 24; by Honda T, Inui M. et al..PMID:31980707
, (2020),
PMID:
31980707
et al,BAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer.In Cancer Cell Int on 2013 Jun 1 by Jiang L, Luo M, et al..PMID:23725574
, (2013),
PMID:
23725574
et al,Apoptosis sensitization by Euphorbia factor L1 in ABCB1-mediated multidrug resistant K562/ADR cells. In Molecules on 2013 Oct 16 by Tao Yi, Yi-Na Tang, et al..PMID:
24135937
, (2013),
PMID:
24135937
et al,Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro Molecules on 2015 Jun 22 by Jian-Ye Zhang , Min-Ting Lin et al..PMID:26111180
, (2015),
PMID:
26111180
et al,L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway InJ Orthop Surg ResOn2023 May 26byTaiyang Liao , Wei Mei et al..PMID:37237380
, (2023),
PMID:
37237380
查看更多
et al,Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.In Am J Cancer Res on 2016 Mar 15 by Jian-Ye Zhang, Min-Ting Lin et al..PMID: 27186433
, (2016),
PMID: 27186433
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