产品详情
产品名称Smad1/Smad5/Smad8 Antibody
来源种属Rabbit
克隆性Polyclonal
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total Smad1, Smad5, Smad8 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.461-465(I-S-S-V-S) derived from Human Smad1. This sequence has the same homology in Smad5 and Smad8.
基因/蛋白名称Smad1/Smad5/Smad8
标记Unconjugated
别名 Mad-related protein 1, SMAD 1, hSMAD1, Transforming growth factor-beta-signaling protein 1,
Uniprot
Q15797
浓度1.0mg/ml
应用详情
Predicted MW: 60kd
Western blotting: 1: 500~1: 1000
Western blot analysis of extracts from 3T3 cells using Smad1/Smad5/Smad8 Antibody #21684.
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.
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et al,Hepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling. In Life Sci on 2024 Nov 12 by Manar M Esmail, Noha M Saeed,et al..PMID:39537098
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