产品详情
产品名称PEX19 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Purified by antigen-affinity chromatography.
应用WB IHC IF
种属反应性Human
免疫原类型Recombinant protein
免疫原描述Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 269 of PEX19
基因/蛋白名称PEX19
标记Unconjugated
数据库入口号NCBI Gene ID: 5824
NCBI mRNA#: NM_002857
NCBI Protein#: NP_002848
浓度1mg/ml
配方Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
应用详情
Predicted MW: 33kd
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:500
Immunofluorescence: 1:100-1:200
Sample (30 ug of whole cell lysate)
A: Raji
B: K562
C: THP-1
D: NCI-H929
12% SDS PAGE
Primary antibody diluted at 1: 10000
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using PEX19 antibody at 1: 500 dilution.
Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using PEX19 antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2000.
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq]
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