产品详情
产品名称JNK1 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Purified by antigen-affinity chromatography.
应用WB IF
种属反应性Human
免疫原类型Recombinant protein
免疫原描述Recombinant protein fragment contain a sequence corresponding to a region within amino acids 5 and 270 of JNK1
基因/蛋白名称JNK1
标记Unconjugated
数据库入口号NCBI Gene ID: 5599
NCBI mRNA#: NM_139049
NCBI Protein#: NP_620637
浓度0.4mg/ml
配方Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
应用详情
Predicted MW: 48kd
Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200
Sample (30 ug of whole cell lysate)
A: Raji
10% SDS PAGE
Primary antibody diluted at 1: 1000
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using JNK1 antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2000.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
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et al,Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-魏 B and MAPK pathways.In Connect Tissue Res on 2015 Jun by Vishwa Deepak , Abe Kasonga et al..PMID:25405641
, (2015),
PMID:
25405641
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