产品详情
产品名称PDE4D antibody
来源种属Rabbit
克隆性Polyclonal
纯化Purified by antigen-affinity chromatography.
应用WB IHC IF
种属反应性Human
免疫原类型Peptide
免疫原描述Synthetic peptide contain a sequence corresponding to a region within amino acids 610 and 673 of PDE4D
基因/蛋白名称PDE4D
标记Unconjugated
别名DPDE3; STRK1; HSPDE4D; PDE4DN2
数据库入口号NCBI Gene ID: 5144
NCBI mRNA#: NM_006203
NCBI Protein#: NP_006194
浓度0.3mg/ml
配方Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
应用详情
Predicted MW: 76kd
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:250
Immunofluorescence: 1:100-1:200
Sample (30 ug of whole cell lysate)
A: A431
B: HeLa
7.5% SDS PAGE
Primary antibody diluted at 1: 1000
Immunohistochemical analysis of paraffin-embedded H441 xenograft, using PDE4D antibody at 1: 100 dilution.
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed A431, using PDE4D antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 500.
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003 [PubMed 14517535]).[supplied by OMIM]
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et al,Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D.In J Exp Clin Cancer Res. On 2018 Nov 27 by Qiang Z, Zhou ZY et al..PMID: 30482227
, (2018),
PMID:
30482227
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