产品详情
产品名称DR5 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB ICC
种属反应性Human;Mouse
特异性Antibody has no cross reaction to DR4.
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor.
基因/蛋白名称DR5
标记Unconjugated
别名DR5, TRAIL-R2
数据库入口号AF012535
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.
如果您使用该产品24041发表了文章，请通知我们，让我们可以引用您的文献。
et al, Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway.In Oncotarget
on 2016 Nov 8 by Sai-Qi Wang , Cong Wang et al..PMID: 27659528
, (2016),
PMID:
27659528
有货
