产品详情
产品名称BACE Antibody
来源种属Rabbit
克隆性Polyclonal
纯化BACE Antibody is affinity chromatography purified via peptide column.
应用ELISA WB ICC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
基因/蛋白名称BACE
标记Unconjugated
别名Asp
数据库入口号AF190725
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Predicted MW: 70 kd
Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL.
Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 ug/mL.
Immunofluorescence of BACE in 3T3 cells with BACE antibody at 20 μg/ml.
Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
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et al,Oral Treponema denticola Infection Induces A尾1锟?0 and A尾1锟?2 Accumulation in the Hippocampus of C57BL/6 Mice. In J Mol Neurosci on 2021 Jul by Xinyi Su 1, Zhiqun Tang, et al..PMID: 33763842
, (2021),
PMID:
33763842
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