产品详情
产品名称Ski Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IF
种属反应性Human
免疫原类型Peptide
免疫原描述Raised against a 14 amino acid peptide from near the amino terminus of human Ski.
基因/蛋白名称Ski
标记Unconjugated
别名c-ski, v-ski sarcoma viral oncogene homolog
数据库入口号P12755
Uniprot
P12755
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Ski in human kidney tissue lysate with Ski antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 ug/mL.
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
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et al,Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. In Drug Dev Res on 2022 Jun by Feng Wang, Jun Zhang,et al..PMID:35277868
, (2022),
PMID:
35277868
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