产品详情
产品名称TLR4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA IHC
种属反应性Human
特异性TLR4 antibody is predicted to not cross-react with other TLR protein family members.
免疫原类型Peptide
免疫原描述Raised against a 14 amino acid peptide near the carboxy terminus of human TLR4.
基因/蛋白名称TLR4
标记Unconjugated
别名Toll-like receptor 4
数据库入口号NP_612564
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Immunohistochemistry of TLR4 in human placenta tissue with TLR4 antibody at 5 ug/mL.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
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, (2021),
PMID:
34162400
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