产品详情
产品名称Bcl-2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Bcl-2 Antibody is affinity chromatography purified via peptide column.
应用ELISA WB ICC
种属反应性Human
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to 14 amino acids near the middle of human Bcl-2.
基因/蛋白名称Bcl-2
标记Unconjugated
数据库入口号AAH27258
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Bcl-2 in A-20 cell lysates with Bcl-2 antibody at (A) 1, (B) 2, and (C) 4 ug/mL.
Immunocytochemistry of Bcl-2 in A20 cells with Bcl-2 antibody at 2 ug/mL.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis. It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad. Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
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et al,BAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer.In Cancer Cell Int on 2013 Jun 1 by Jiang L, Luo M, et al..PMID:23725574
, (2013),
PMID:
23725574
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