产品详情
产品名称XBP-1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
基因/蛋白名称XBP-1
标记Unconjugated
别名X box binding protein 1, Tax-responsive element binding protein 5
数据库入口号BAB82982
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 10 ug/mL.
Immunofluorescence of XBP-1 in HepG2 cells with XBP-1 antibody at 20 μg/ml.
X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
如果您使用该产品24385发表了文章，请通知我们，让我们可以引用您的文献。
et al,CLOCK disruption aggravates carotid artery stenosis through endoplasmic reticulum stress-induced endothelial-mesenchymal transition. In Am J Transl Res on 2020 Dec 15 by Hanfei Tang, Song Xue, et al..PMID:33437367
, (2020),
PMID:
33437367
有货
