产品详情
产品名称Slug Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IF
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 13 amino acid peptide from near the center of human Slug.
基因/蛋白名称Slug
标记Unconjugated
别名Neural crest transcription factor slug, Snail homolog 2
数据库入口号O43623
Uniprot
O43623
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Slug in 293 cell lysate with Slug antibody at in (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunofluorescence of Slug in human kidney tissue with Slug antibody at 20 ug/mL.
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
如果您使用该产品24463发表了文章，请通知我们，让我们可以引用您的文献。
et al,Nanosized functional miRNA liposomes and application In the treatment of TNBC by silencIng Slug gene. In Int J NanomedicIne. on 2019 May 17 by Yan Y, Li XQ, et al..PMID:31190817
, (2019),
PMID:
31190817
et al,Glycogen Phosphorylase B Is Regulated by miR101-3p and Promotes Hepatocellular Carcinoma Tumorigenesis. In Front Cell Dev Biol on 2020 Nov 25 by Guangying Cui, Huifen Wang, et al..PMID:33324633
, (2020),
PMID:
33324633
et al,Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma. In Cancer Gene Ther on 2022 Nov 10 by Jing Wang, Tie-Jun Huang, et al..PMID:36357564
, (2022),
PMID:
36357564
et al,Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinomaInCancer Gene TherOn2023 FebbyJing Wang?1,?Tie-Jun Huang et al..PMID:?36357564
, (2023),
PMID:
36357564
有货
