产品详情
产品名称LKB1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide from near the carboxy terminus of human LKB1.
基因/蛋白名称LKB1
标记Unconjugated
别名Serine-threonine protein kinase 11, STK11, NT-REN-19 antigen
数据库入口号AAH19334
Uniprot
AAH19334
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 ug/mL in the (A) absence or (B) presence of blocking peptide.
The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.
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et al,Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2. In J Transl Med on 2024 Sep 16 by Chao Yang, Xia Zhao,et al..PMID:39285426
, (2024),
PMID:
39285426
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