产品详情
产品名称ORAI2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB ICC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide from near the carboxy terminus of human ORAI2.
基因/蛋白名称ORAI2
标记Unconjugated
别名Transmembrane protein 142B, TMEM142B, Calcium release-activated calcium channel protein 2
数据库入口号Q96SN7
Uniprot
Q96SN7
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of ORAI2 in Jurkat cell lysate with ORAI2 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.
Immunocytochemistry of ORAI2 in Jurkat cells with ORAI2 antibody at 5 ug/mL.
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3.
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et al,A Newly Established Cuproptosis-Related Gene Signature for Predicting Prognosis and Immune Infiltration in Uveal MelanomaInInt J Mol SciOn2023 Jul 12byWei Huang?1?2,?Fan Yang et al..PMID:?37511120
, (2023),
PMID:
37511120
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