产品详情
产品名称IFN-beta Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse
免疫原类型Peptide
免疫原描述Raised against a 17 amino acid peptide from near the center of human IFN-b.
基因/蛋白名称IFN-beta
标记Unconjugated
别名Interferon beta, beta-interferon
数据库入口号AAC41702
Uniprot
AAC41702
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of IFN-b in A-20 cell lysate with IFN-b antibody at 5 ug/mL.
Immunohistochemistry of IFN-b in human liver tissue with IFN-b antibody at 5 ug/mL.
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
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et al,Sustained induction of IP-10 by MRP8/14 via the IFNβ–IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice
, (2023),
PMID:
37701855
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