产品详情
产品名称STEAP1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
特异性This STEAP1 antibody does not cross-react with other STEAP proteins.
免疫原类型Peptide
免疫原描述Raised against a 18 amino acid peptide from near the carboxy terminus of human STEAP1.
基因/蛋白名称STEAP1
标记Unconjugated
别名Six transmembrane epithelial antigen of prostate 1, STEAP
数据库入口号EAL24166
Uniprot
EAL24166
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of STEAP1 in human spleen tissue lysate with STEAP1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of STEAP1 in human spleen tissue with STEAP1 antibody at 2.5 ug/mL.
The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.
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, (2023),
PMID:
36860893
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