产品详情
产品名称TEM2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of the human TEM2.
基因/蛋白名称TEM2
标记Unconjugated
别名Tumor endothelial marker 2, Ras homolog enriched in striatum, Rhes, RASD2
数据库入口号Q96D21
Uniprot
Q96D21
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of TEM2 in human colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of TEM2 in human colon tissue with TEM2 antibody at 2.5 ug/mL.
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
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PMID:
36589543
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