产品详情
产品名称Wnt10a Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
特异性Despite the high homology of Wnt10a to Wnt10b, this Wnt10a antibody will not cross-react with Wnt10b.
免疫原类型Peptide
免疫原描述Raised against a 14 amino acid peptide from near the carboxy terminus of human Wnt10a.
基因/蛋白名称Wnt10a
标记Unconjugated
别名Wnt10a, Wingless-type MMTV integration site family 10a
数据库入口号Q9GZT5
Uniprot
Q9GZT5
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Wnt10a in RAW264.7 cell lysate with Wnt10a antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of Wnt10a in human skeletal muscle tissue cells with Wnt10a antibody at 10 ug/mL.
Immunohistochemistry of Wnt10a in mouse skeletal muscle tissue with Wnt10a antibody at 5 μg/ml.
Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.
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et al,Reforming the Chimeric Antigen Receptor by Peptide Towards Optimized CAR T Cells With Enhanced Anti-Cancer Potency and Safety.In Front Bioeng Biotechnol. 2022 Jun 17 by Cuijuan Liu , Lin Li , Fan Gao,,et al.PMID: 35782491
, (2022),
PMID:
35782491
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