产品详情
产品名称Alpha-tubulin Antibody
来源种属Chicken
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 16 amino acid peptide near the amino terminus of human Tubulin.
基因/蛋白名称Alpha-tubulin
标记Unconjugated
别名Alpha-tubulin, Tubulin alpha-1A, TUBA1A, TUBA3, LIS3
数据库入口号CAA25855
Uniprot
CAA25855
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Tubulin in rat brain tissue lysate with Tubulin antibody at (A) 0.5 and (B) 1 ug/mL.
Alpha-tubulin belongs to the tubulin superfamily, which is composed of six distinct families. Along with beta-tubulins, alpha-tubulins are the major components of microtubules. These microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Alpha- and beta-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha-tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase. Another post-translational modification of detyrosinated alpha-tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle. Like GAPDH and beta-Actin, this antibody makes an excellent loading control in immunoblots.
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