产品详情
产品名称FOXO1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB ICC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the amino terminus of human FOXO1.
基因/蛋白名称FOXO1
标记Unconjugated
别名Forkhead box O1, FKH1, FKHR, Forkhead in rhabdomyosarcoma, FOXO1A
数据库入口号NP_002006
Uniprot
NP_002006
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of FOXO1 in Hela cell lysate with FOXO1 antibody at 1 ug/mL.
Immunocytochemistry of FOXO1 in HeLa cells with FOXO1 antibody at 4 ug/mL.
FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.
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et al,Dynamic Impacts of Stock Enhancement on Kaluga Sturgeon (Huso dauricus): Novel Conservation Strategy Insights from the Gut Microbe Composition and Gene Expression Mode.
, (2025),
PMID:
40003945
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