产品详情
产品名称CCDC106 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of human CCDC106.
基因/蛋白名称CCDC106
标记Unconjugated
别名Coiled-coil domain containing protein 106, ZNF581, HSU79303
数据库入口号NP_037433
Uniprot
NP_037433
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of CCDC106 in human brain tissue lysate with CCDC106 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of CCDC106 in rat brain tissue with CCDC106 antibody at 5 ug/mL.
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
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et al,CK2-mediated CCDC106 phosphorylation is required for p53 degradation In cancer progression. In J Exp ClIn Cancer Res on 2019 Mar 18 by NIng Y, Wang C, et al..PMID: 30885251
, (2019),
PMID:
30885251
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