产品详情
产品名称STAU1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of human STAU1.
基因/蛋白名称STAU1
标记Unconjugated
别名RNA-binding protein Staufen homolog 1, STAU
数据库入口号NP_059347
Uniprot
NP_059347
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of STAU1 in rat brain tissue lysate with STAU1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of STAU1 in human brain tissue with STAU1 antibody at 10 ug/mL.
STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
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et al,Expression and Significance of Staufen1 in the Placenta in Severe Preeclampsia
, (2019),
PMID:
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