产品详情
产品名称DC-SIGN Monoclonal Antibody
克隆号mAb (Clone 8B6)
来源种属Mouse
克隆性Monoclonal
纯化Immunoaffinity chromotography purified IgG
应用ELISA WB IHC
种属反应性Human
免疫原类型Recombinant protein
免疫原描述A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
基因/蛋白名称DC-SIGN
标记Unconjugated
别名DC-SIGN (8B6), Dendritic cell-specific ICAM-3-grabbing nonintegrin 1
数据库入口号Q9NNX6
Uniprot
Q9NNX6
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year.
应用详情
Western blot detection of DC-SIGN fusion protein in human uterus tissue lysate at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of DC-SIGN in lymph node tissue with DC-SIGN antibody at 10 ug/mL.
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes , where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
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