产品详情
产品名称ATP1A Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human ATP1A (NP_000692.2).
标记Unconjugated
别名ATP1A1; ATPase Na+/K+ transporting subunit alpha 1
数据库入口号Swiss-Prot#:P05023
NCBI Gene ID:476/477/478/480
Uniprot
P05023
计算分子量113kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IP 1:50 - 1:100
Western blot analysis of extracts of HeLa cells, using ATP1A antibody at 1:500 dilution.
Western blot analysis of extracts of various cell lines, using ATP1A1 antibody at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded human prostate using ATP1A1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using ATP1A1 antibody at dilution of 1:100 (40x lens).
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
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et al,ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells.In Int J Mol Sci. 2022 Oct 15 by Valentina E Gómez-Mellado, Jung-Chin Chang , et al..PMID:36293199
, (2022),
PMID:
36293199
Yes
