产品详情
产品名称SIRT1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human SIRT1
标记Unconjugated
别名SIR2;SIR2L1;SIR2alpha;SIRT1;sirtuin 1
数据库入口号Uniprot:Q96EB6
GeneID:23411
Uniprot
Q96EB6
Gene ID
23411
计算分子量82kDa
实际分子量120kDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using SIRT1 antibody.
Immunohistochemistry of paraffin-embedded Mouse heart using SIRT1 antibody.
Immunofluorescence analysis of C6 cells using SIRT1 antibody.
Immunofluorescence analysis of NIH-3T3 cells using SIRT1 antibody.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
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et al,Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. In J Transl Med
on 2024 Feb 15 by Jing Li, Xiaochen Wang,et al..PMID:38360728
, (2024),
PMID:
38360728
Yes
