产品详情
产品名称TIM3 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human TIM3 (NP_116171.3).
标记Unconjugated
别名HAVCR2; CD366; HAVcr-2; KIM-3; TIM3; TIMD-3; TIMD3; Tim-3; hepatitis A virus cellular receptor 2
数据库入口号Swiss-Prot#:Q8TDQ0
NCBI Gene ID:84868
Uniprot
Q8TDQ0
计算分子量33kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using TIM3 antibody.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
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et al,Tumor-associated macrophages promoting PD-L1 expression in infiltrating B cells through the CXCL12/CXCR4 axis in human hepatocellular carcinoma. In Am J Cancer Res on 2024 Feb 15 by Sen-Lin Lian, Yun-Tao Lu,et al..PMID:38455420
, (2024),
PMID:
38455420
et al,SLC35A2 expression drives breast cancer progression via ERK pathway activation
, (2023),
PMID:
Yes
