产品详情
产品名称PD-L1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human PD-L1 (NP_054862.1).
标记Unconjugated
别名B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274
数据库入口号GeneID:29126
Swiss Prot:Q9NZQ7
Uniprot
Q9NZQ7
计算分子量20kDa/33kDa
实际分子量45kDa
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 171% glycerol.
保存Store at -20˚C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.124.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
Immunohistochemistry of paraffin-embedded human colon carcinoma using PD-L1 antibody at dilution of 1:100 .
Western blot analysis of extracts of A-549 cells, using PD-L1 antibody at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded mouse spleen using PD-L1 antibody at dilution of 1:100 .
Immunohistochemistry of paraffin-embedded rat spleen using PD-L1 antibody at dilution of 1:100 .
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
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et al,Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapyIn Cell Rep.On2023 May 30byQicong Luo , Zinan Dong et al..PMID:37097818
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PMID:
37097818
et al,Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer.
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PMID:
39488900
Yes
