产品详情
产品名称NOTCH1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述A synthetic peptide of human NOTCH1
标记Unconjugated
别名NOTCH1; AOS5; AOVD1; TAN1; hN1; notch 1
数据库入口号Swiss-Prot#:P46531
NCBI Gene ID:4851
Uniprot
P46531
计算分子量300kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NOTCH1 antibody.
Western blot analysis of extracts from normal (control) and NOTCH1 knockout (KO) HeLa cells, using NOTCH1 antibody.
Immunofluorescence analysis of U2OS cells using NOTCH1 antibody.
Immunohistochemistry of paraffin-embedded rat spleen using NOTCH1 antibody.
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
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et al,DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway. In Am J Cancer Res on 2021 Jun 15 by Xiaojing Zhang, Huiqin Bian, et al..PMID:34249467
, (2021),
PMID:
34249467
et al,Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.
, (2025),
PMID:
40177488
et al,Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.
, (2025),
PMID:
40177488
货期一周
